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4.5 out of 5 based on 4 customer ratings
(4 customer reviews)


Adrafinil is a synthetic compound with nootropic like effects. It is a prodrug of modafinil, both of which shares similar structure. As a prodrug, adrafinil increases the production of modafinil in the body. Researches have shown that adrafinil has the ability to activate behavioural arousal without causing any undesirable effects.

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  • Overview


    Adrafinil is a synthetic compound with nootropic like effects. It is a prodrug of modafinil, both of which shares similar structure. As a prodrug, adrafinil increases the production of modafinil in the body. Researches have shown that adrafinil has the ability to activate behavioural arousal without causing any undesirable effects. This exceptional characteristic is the primary reason why adrafinil has been grouped under the “eurgeroic” pharmaceutical category [1], [2], [3], [4].

    Earlier clinical studies have shown that adrafinil is effective in treating memory problems, sleeping difficulties, arousal/vigilance deficits, depression and voluntary movement deficits amongst the elderlies. These studies however are mostly done in France and have not been replicated since on other countries [1]. Majority of studies undertaken to assess and evaluate the effects of adrafinil are done using non-human models such as rats, canines and monkeys [1], [2], [4].

    Key findings
    • Promotes vigilance and arousal [1].
    • Increased locomotor activity [1], [4].
    • Increased learning [3].
    • Improved motivation [3].
    • Reduction of immobility [5].
    • Anti-depressant like effects [5].

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  • Description

    Product Description

    Please note: This description is for informational purposes only. We do not encourage intake of adrafinil or any other nootropic substance listed/discussed/sold on this site. Only buy adrafinil for research. This product is strictly intended for research purposes only.



    In non-human studies, adrafinil is able to increase the arousal and locomotor activities of aged canines without causing any stereotypical activities (e.g. stereotypical behaviour, increased heart rate, high blood pressure, anxiety tolerance and dependence. Size discrimination was enhanced and adrafinil appears to cause prolonged electroencephalographic activity [1], [4]. In a similar test (open-field study) comparing adrafinil, nicergoline and propentofylline, only adrafinil demonstrated significant effects on alertness, behavioural, and memory improvement [9].

    One clinical study comparing placebo and adrafinil revealed that the latter is able to effectively enhance learning. This was evidenced by the marked decrease of both trials and errors after doses of adrafinil as compared to placebo use [3].

    Though the World Anti-Doping Agency bans both adrafinil and modafinil for athletes’ use during competitive sports, the US Food and Drug Administration (FDA) have approved modafinil as a treatment for narcolepsy or hypersomnolence. The US FDA also approved modafinil therapy for other sleep related disorders such as obstructed sleep apnoea (OSA)[10], [12].

    Similar to adrafinil, modafinil is able to promote wakefulness and alertness amongst users as well as locomotor activities amongst non-human models [10], [11]. Some studies have also shown that it is effective in treating substance addiction and has neuroprotective properties[10], [12], [13], [14]. Modafinil is able to exert its effects without causing ensuing rebound hypersomnolence usually seen in caffeine. Undesirable effects such as increased heart rate, stereotypical behaviors, dependence, tolerance, appetite problems, high blood pressure, anxiety and anorexia are unlikely to be seen with modafinil and adrafinil use [1], [11], [12].

    How does Adrafinil and Modafinil work and why you should buy Adrafinil?

    The mechanism of action for both adrafinil and modafinil is yet to be discovered. Theorists however hypothesized that both drugs have an antagonistic effect on the central nervous system’s (CNS) noradrenergic system. It is said to exert its impact on the post-synaptic alpha-1 receptors. Alpha-1 agonists function through decreasing or preventing the locomotor activities enhancing effects of adrafinil. Another reason to buy Adrafinil is that it helps in increasing hypocretin production in the hypothalamus. Hypocretin is a neurotransmitter that helps in the production of other critical neurotransmitter including norepinephrine, dopamine and histamine [4], [6], [7] . Other mechanism attributed to modafinil and adrafinil include the ability of these drugs to prevent (GABA) release. Prevention of GABA passage and/or increased cerebral metabolism leads to alertness and wakefulness [1].

    The properties of these novel compounds – modafinil and adrafinil as reflected in numerous studies and accounts show that both are potent nootropic compounds. However, further human and non-human studies are needed to further explore its potential benefits as well as ensure its safety and efficacy.

  • Reviews (4)
    4.50 out of 5

    4 reviews for Adrafinil

    1. 4 out of 5


      I have been swamped with work a lot and often get overfatigued, but adrafinil has really helped in that area. My mood has really improved too. Great product!

    2. 4 out of 5


      Being a student who wants to stay up longer to study, I decided to try adrafinil. So far, I am happy with the result. I have been able to stay awake far longer than I used to, and my mind is also more focused.

    3. 5 out of 5


      Great product for the price! I used to take modafinil, but now I know Adrafinil can have the same effects on me. It really helps my mind focus and work, and I have become really motivated as I finish more things. Thanks a lot for the supply!

    4. 5 out of 5


      I have been using Modafinil and the past, until I switched to adrafinil. I really hated the side effects of Modafinil which includes being extra irritable and anxious, which I never experienced with Adrafinil. For me they had same effect, keeping me alert all day.

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  • Analysis
  • References

    Adrafinil – Cited Sources

    [1] http://www.ncbi.nlm.nih.gov/pubmed/11191710

    [2] http://www.ncbi.nlm.nih.gov/pubmed/13679229

    [3] http://www.ncbi.nlm.nih.gov/pubmed/10880682

    [4] http://www.ncbi.nlm.nih.gov/pubmed/10880681

    [5] http://www.ncbi.nlm.nih.gov/pubmed/3713198

    [6] http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654794/pdf/NDT-3-349.pdf

    [7] http://www.ncbi.nlm.nih.gov/pubmed/11191710

    [8] http://www.ncbi.nlm.nih.gov/pubmed/228945

    [9] http://www.ncbi.nlm.nih.gov/pubmed/11108188

    [10] http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654794/pdf/NDT-3-349.pdf

    [11] http://www.ncbi.nlm.nih.gov/pubmed/228945

    [12] http://www.ncbi.nlm.nih.gov/pubmed/16142993

    [13] http://www.ncbi.nlm.nih.gov/pubmed/9353396

    [14] http://www.ncbi.nlm.nih.gov/pubmed/2906157

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