Developed in 1959, Centrophenoxine (Lucidril, Centro or Meclofenoxate) is one of the earliest nootropics discovered at the French Scientific Research Center. Centrophenoxine has a DMAE (Dimethylaminoethanol) component to it, meaning that it essentially has similar effect to those of DMAE, as a cholinergic, however it allows for a better transporter for DMAE into the brain.
Developed in 1959, Centrophenoxine (Lucidril, Centro or Meclofenoxate) is one of the earliest nootropics discovered at the French Scientific Research Center. Centrophenoxine has a DMAE (Dimethylaminoethanol) component to it, meaning that it essentially has similar effect to those of DMAE, as a cholinergic, however it allows for a better transporter for DMAE into the brain. DMAE is an organic compound found in plants.
For many years Centrophenoxine has been well studied as a potent nootropic supplement, with varying benefits to those suffering from age related disorders such as senile dementia and Alzheimer’s disease. Centrophenoxine has been found to reverse the effects of some signs of aging by “mopping” up waste products in the brain. The cognitive benefits of Centrophenoxine a well backed by a long history of research for over 50 years of work.Key Findings
- Found to improve long term memory consolidation, mental alertness and mood.
- Has been found, not only to improve language understanding, but also problem solving, decision making and overall
- Has been found to act as an anti-oxidant, as well as increase RNA synthesis, protein synthesis and glucose uptake.
- Found to be efficacious in treating dementia and shows anti-aging effects.
In 1977 a study to decipher the effect of Centrophenoxine on memory was conducted, double-blind, on able, healthy elderly individuals. After a battery of cognitive tests it was found that Centrophenoxine increased the consolidation of novel information in to long-term memory, with a significant increase in general mental alertness also found.
After some initial hypothesise, it was suggested that a study should be conducted to determine the role of Centrophenoxine in differing emotional states. In 2003 a double blind, placebo controlled study, set out to induce differing emotional states using 80 subjects, half male and half female. Using excerpts from films, the electrical activity of the participant’s brains were measured to determine their emotional state. Each excerpts was shown to three groups: One group received a placebo, the other received 6 weeks of dosing and a final group received 12 weeks of dosing. The conclusion of this study found that participants who were subject to Centrophenoxine for 12 weeks were more alert and had an elevated mood.
How does it Work
It seems from initial research that Centrophenoxine is able to reverse lipofuscin/beta-amyloid pigmentation build up within the brain (one of the build-up products thought to play a role in Alzheimer’s), and have anti-oxidant effects against lipid peroxidation. An increase in RNA, protein and glucose synthesis/uptake has also been seen in glial cells.
One interesting finding was that of the somewhat unique ability of Centrophenoxine to increase the intracellular water content, where intracellular dehydration is consistent with ageing.
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Centrophenoxine – Cited Sources