Tianeptine sulfate is an improved form of tianeptine which will not turn hard when exposed to air, but will remain as powder. It also has a longer half-life. Tianeptine is a popular tricyclic agent with a distinctive neurochemical profile characterized by a long horizontal chain known as heptanoic acid. It has similar physiognomies with amineptine – a dopamine uptake selective inhibitor .
Tianeptine sulfate is an improved form of tianeptine which will not turn hard when exposed to air, but will remain as powder. It also has a longer half-life. During the recent years, tianeptine sulfate has attracted attention from neurologists, particularly experts in the field of depression. Studies on this substance have generated decent literature that defies earlier knowledge about depression. These clinical trials have showcased the efficiency of tianeptine sulfate as an antidepressant. The ability of this substance to treat symptoms of depression has been associated with its excellent neurobiological properties. Primarily, tianeptine sulfate is involved with glutamatergic activities in the brain whereas glutamate is known to play an important role in depression symptoms occurrence .Key Findings
Tianeptine sulfate is also less likely to be subjected to abuse. It has an excellent pharmacokinetic profile whereas it is able to decrease neuronal death caused by stress, has increased bioavailability, limited distribution, immediate elimination, and does not cause detrimental hepatic metabolism   . The measurable effects of tianeptine alongside its early onset identify this compound as a useful antidepressant agent.
- Non-hygroscopic, will not absorb moisture from the air, remains a powder 
- Longer half life compared to the original tianeptine sodium 
- Has anxiolytic effects     
- Exerts anti-depressant effects    
- Protects neuronal cells 
- Improves mental clarity, critical thinking and memory 
- Promotes cytogenesis of the brain 
- Reduces neuropathic pain 
Please note: This article is for informational purposes only. Only buy tianeptine sulfate for research. We do not encourage intake of tianeptine sulfate or any other nootropic substance listed/discussed/sold on this site.
Tianeptine sulfate benefits
Numerous studies have shown the efficacy of tianeptine sulfate in attenuating stress amongst study subjects. For instance, one study using animal subjects revealed that tianeptine has the ability to attenuate morphological changes in the hippocampus caused by stress . This finding was reinforced by another study whereas it was discovered that the ability of tianeptine to regulate extracellular glutamate levels dendritic remodeling of pyramidal neurons helps prevent anxiety as well as the other symptoms of stress . The general anxiolytic properties of tianeptine are comparable to popular anxiolytic agents such as fluoxetine, imipramine and amitriptyline and may even be better than submaximal dosages of maprotiline and amitriptyline .
Therapeutic improvements were evident amongst patients suffering from depressed bipolar disorder as well as major and endogenous depression. Its use amongst the elderlies and post alcohol withdrawal patient groups has been very successful. Prolonged tianeptine use was even identified to be effective in reducing recurrence or relapse amongst users . One study identified that the anti-depressant effects of tianeptine is associated to its ability to protect temporal cortex and hippocampal areas from apoptosis or cell death  .
Brain cytogenesis properties
Tianeptine has the ability to promote brain cytogenesis through reducing neuronal cell death. It also has cytoprotective effects preventing the damage caused by pro-inflammatory cytokines found in the brain. As a result, tianeptine is able to prevent the detrimental effects of prolonged stress states whilst be able to help enhance depression symptoms .
One notable beneficial effects associated with tianeptine sulfate includes its ability to improve memory, mental and critical thinking ability. Anecdotal evidence and clinical trials (though limited) have shown that this substance is able to exert these brain-enhancing effects through repairing morphological modifications caused by hippocampal shrinkage and stress  .
Several reports have shown that tianeptine sulfate has antinociceptive effects. It is able to modulate GABAergic interneurons in the spinal cord to reduce neuropathic pain. One animal study have shown that introduction of tianeptine sulfate was able to decrease neuropathic pain experienced by the subjects induced by spinal nerve ligation .
How tianeptine sulfate works and why you should buy tianeptine sulfate
Most people decide to buy tianeptine sulfate a.k.a (Tianeptine hemisulfate monohydrate) instead of the original tianeptine sodium salt because it is not hygroscopic, which means unlike the original version of tianeptine it will not turn hard when exposed to air, but will remain in its very usable and stable powder form. This mean it’s much easier to work with. Also this improved tianeptine sulfate has a longer half life.
In terms of its structure (a modified tricyclic agent) and pharmacodynamics profile, this substance is a bonafide unique antidepressant agent. It is so unlike other antidepressants whereas it stimulates serotonin uptake, decreases behaviors induced by serotonergic intake and increases in 5-HIAA or 5 hydroxyindoleactive acid levels. It also acts on the HPA (hypothalamic-pituitary-adrenal) response towards stress. In addition to this, tianeptine has the ability to antagonise behavioral deficits/activities caused by stress whilst be able to prevent undesirable changes on cerebral morphology .
Tianeptine’s most celebrated mechanism of action includes its ability to prevent hippocampal changes. Primarily, tianeptine has direct influence towards extracellular glutamate levels. Research have shown that this substance dendritic remodeling on specific areas in the hippocampus whilst suppresses dentate gyrus neurogenesis which ultimately leads to improved neuroplasticity and prevention of depressive and anxiety symptoms  .
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